Start a new game for the first time. (any difficulty setting)
Story Progression in Act 1 - Chapter 1 (any difficulty setting)
Story Progression in Act 4 - Chapter 1 (any difficulty setting)
Story Progression in Act 4 - Chapter 2 (any difficulty setting)
Story Progression in Act 4 - Chapter 3 (any difficulty setting)
Story Progression in Act 4 - Chapter 4 (any difficulty setting)
Story Progression in Act 4 - Chapter 5 (any difficulty setting)
Story Progression in Act 4 - Chapter 6 (any difficulty setting)
Story Progression in Act 5 - Chapter 1 (any difficulty setting)
Story Progression in Act 5 - Chapter 2 (any difficulty setting)
Story Progression in Act 5 - Chapter 3 (any difficulty setting)
Story Progression in Act 5 - Chapter 4 (any difficulty setting)
Story Progression in Act 2 - Chapter 1 (any difficulty setting)
Story Progression in Act 5 - Chapter 5 (any difficulty setting)
Defeat George Human Boss
Defeat George Beast Boss
Defeat Maras Grim (Sister Grim) Boss
Defeat Kauline Grim (Sister Grim) Boss
Defeat Elliot Beast Boss
Defeat Giltine Grim (Sister Grim) Boss
Defeat Justine Boss
Defeat Fleming Boss
Secret
Story Progression in Act 2 - Chapter 2 (any difficulty setting)
Complete all chapters on Easy difficulty setting
Complete all chapters on Medium difficulty setting
Complete all chapters on Hard difficulty setting
Defeat 10 enemies with the Stomp Attack
Defeat 20 enemies with the TEETHER
Defeat 30 enemies with the SKULLCUSSIONER
Defeat 20 enemies with the HOTBONER
Defeat 30 enemies with the TEETHGRINDER
Defeat 40 enemies with the SKULLFEST 9000
Perform 5 headshots in a row with the BIG BONER
Story Progression in Act 2 - Chapter 3 (any difficulty setting)
Defeat 50 enemies with THE DENTIST
Defeat 50 enemies with the SKULLBLASTER
Perform 5 Head Shots in a row with any weapon except Big Boner
Perform a Head Shot right after a Leg Mutilation when the enemy is flying back in the air
Defeat 3 enemies at once using the Barrels of Light
Defeat 5 enemies at once using the Hot Boner
Perform all 5 brutal kills on Normal Demons frozen by the Light Shot
Knock back 3 drinks in a row
Save more than 300 White Gems in your inventory
Recover all available Red Gems in the game.
Story Progression in Act 2 - Chapter 4 (any difficulty setting)
Story Progression in Act 3 - Chapter 1 (any difficulty setting)
Story Progression in Act 3 - Chapter 2 (any difficulty setting)
Story Progression in Act 3 - Chapter 3 (any difficulty setting)
Story Progression in Act 3 - Chapter 4 (any difficulty setting)
Complete all game's Trophies.