Obtain all upgrades.
Obtain enough items to get a sweet trophy in your room.
Complete a hardcore run of the game.
Complete a run in New Game +2.
Craft an item.
Potion used!
Complete a dungeon.
Activate a new item set.
The gates of hell have opened!
Obtained a legendary item!
Obtain enough Mastery Points to unlock Legendary items in the armory.
Mix two potions.
Upgrade an item by synthesis.