Kill Mom
Hold 55 or more pennies at one time
Have 4 or more soul hearts at one time
Obtain all trophies
Kill Isaac with Isaac
Kill Satan with Cain
Kill Satan
Kill Isaac with Judas
Kill Satan with Judas
Beat 2 levels in a row without picking up any hearts
Kill Isaac with Eve
Kill Satan with Eve
Beat 2 levels in a row without taking damage
Kill Isaac with Samson
Kill Satan with Samson
Kill Satan with Isaac
Make 3 deals with the devil in one run
Kill Isaac with Azazel
Kill Satan with Azazel
Kill Isaac with Lazarus
Kill Satan with Lazarus
Beat the Womb for the first time
Kill Isaac with Eden
Kill Satan with Eden
Beat the Basement 40 times
Kill Isaac with The Lost
Beat the Caves 30 times
Beat the Depths 20 times
Beat the Basement/Cellar without taking damage
Beat the Caves/Catacombs without taking damage
Beat the Depths/Necropolis without taking damage
Beat the Womb/Utero without taking damage
Beat the Chest or Dark Room without taking damage
Beat all 20 Challenges
Beat the Boss Rush
Beat the Dark Room
Kill Satan with The Lost
Beat the Chest
Beat the Dark Room with Isaac
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball
Kill Mom using the Bible
Kill Mom's Heart 3 times
Kill Mom's Heart 5 times
Kill Mom's Heart 8 times
Kill Mom's Heart 9 times
Kill Mom's Heart 10 times
Have 7 or more max red hearts at one time
Kill Mom's Heart 11 times
Kill Satan with ???
Kill all 7 sins
Beat Cathedral 5 times
Beat Sheol 5 times
You are the best!
Collect all items and unlock all secrets and endings
Finish the game's final secret
100% the game
Beat Greed Mode with Azazel
Kill Isaac with Maggy
Kill ??? with Lilith
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill ??? with Keeper
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Kill Delirium with Apollyon
Beat Greedier Mode with Apollyon
Complete all hard mode marks with Apollyon
Kill Hush for the first time
Kill Satan with Maggy
Kill Delirium for the first time
Beat 3 victory laps in one run
Just Stop!
Complete ??? 3 times
Beat Hard mode as Lazarus without losing a life
You are just like your father...
The other side is calling...
Beat everything in Hard Mode as every character
. . .
∞%
Kill Isaac with Cain
