Complete all game's Trophies.
Complete all chapters on Hard difficulty setting
Complete all chapters on Easy difficulty setting
Recover all available Red Gems in the game.
Perform 5 Head Shots in a row with any weapon except Big Boner
Complete all chapters on Medium difficulty setting
Story Progression in Act 5 - Chapter 5 (any difficulty setting)
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Story Progression in Act 5 - Chapter 4 (any difficulty setting)
Defeat Fleming Boss
Story Progression in Act 5 - Chapter 3 (any difficulty setting)
Story Progression in Act 5 - Chapter 2 (any difficulty setting)
Story Progression in Act 5 - Chapter 1 (any difficulty setting)
Defeat 50 enemies with the SKULLBLASTER
Story Progression in Act 4 - Chapter 6 (any difficulty setting)
Defeat Justine Boss
Story Progression in Act 4 - Chapter 5 (any difficulty setting)
Defeat 50 enemies with THE DENTIST
Defeat 20 enemies with the HOTBONER
Story Progression in Act 4 - Chapter 4 (any difficulty setting)
Story Progression in Act 4 - Chapter 3 (any difficulty setting)
Defeat 40 enemies with the SKULLFEST 9000
Defeat Giltine Grim (Sister Grim) Boss
Defeat 30 enemies with the TEETHGRINDER
Story Progression in Act 4 - Chapter 2 (any difficulty setting)
Story Progression in Act 4 - Chapter 1 (any difficulty setting)
Perform 5 headshots in a row with the BIG BONER
Story Progression in Act 3 - Chapter 4 (any difficulty setting)
Defeat Elliot Beast Boss
Story Progression in Act 3 - Chapter 3 (any difficulty setting)
Defeat 5 enemies at once using the Hot Boner
Defeat Kauline Grim (Sister Grim) Boss
Story Progression in Act 3 - Chapter 2 (any difficulty setting)
Story Progression in Act 3 - Chapter 1 (any difficulty setting)
Defeat Maras Grim (Sister Grim) Boss
Defeat 30 enemies with the SKULLCUSSIONER
Story Progression in Act 2 - Chapter 4 (any difficulty setting)
Defeat George Beast Boss
Story Progression in Act 2 - Chapter 3 (any difficulty setting)
Save more than 300 White Gems in your inventory
Defeat 3 enemies at once using the Barrels of Light
Defeat 20 enemies with the TEETHER
Story Progression in Act 2 - Chapter 2 (any difficulty setting)
Defeat George Human Boss
Story Progression in Act 2 - Chapter 1 (any difficulty setting)
Defeat 10 enemies with the Stomp Attack
Perform a Head Shot right after a Leg Mutilation when the enemy is flying back in the air
Perform all 5 brutal kills on Normal Demons frozen by the Light Shot
Knock back 3 drinks in a row
Story Progression in Act 1 - Chapter 1 (any difficulty setting)
Start a new game for the first time. (any difficulty setting)