Unlock all trophies.
Complete the game on Madhouse.
Obtain all of the Antique Coins in Madhouse difficulty.
Complete the game on Normal.
Create all items that contain Chem Fluid and Strong Chem Fluid.
Shoot and knock back Marguerite while she's leaping at you.
Complete the "Happy Birthday" videotape within 5 minutes.
Get ending 2.
Complete the game using only 3 First Aid Meds or less.
Complete the game without opening the Item Box more than 3 times.
Complete the game within 4 hours.
Complete the "Mia" videotape without being spotted by Marguerite.
Get ending 1.
Complete the game on Easy.
Destroy all Mr. Everywhere statuettes.
Read all of the files in a single playthrough.
Escape from the ship.
Obtain all of the Antique Coins in Easy or Normal difficulty.
Kill an enemy by attaching a Remote Bomb to them and detonating it.
Watch all the videotapes in a single playthrough.
Escape from the Baker family home.
Uncover the secret in the old house.
Fight off Marguerite while she wanders the old house to make her run away.
Take down two or more enemies with one shot.
Put an unrelated object on a shadow plinth.
Increase your item slots.
Clear insects off a door using a knife.
Finish off an enemy with the knife.
Escape to the yard.
Avoid Jack's scissor attack by crouching.
Use psychostimulants.
Block an enemy attack by guarding.
Destroy a Mr. Everywhere statuette.
Escape from the guest house.
Use a lock pick to open something.
Close an open door by yourself.
Obtain something by closely examining an item.
Travel to Louisiana.
Complete Nightmare.
Complete Night Terror.
Complete Bedroom.
Find all the dead rats in Bedroom in a single play.
Complete Ethan Must Die.
Complete 21.
Complete Survival mode in 21.
Complete Survival+ mode in 21.
Get the bad ending in Daughters.
Get the true ending in Daughters.
Clear a stage with a 10 minute time bonus or higher in Jack's 55th Birthday.
Feed Jack every type of food and drink in Jack's 55th Birthday.
Get an S Rank or higher on all stages in Jack's 55th Birthday.
Complete End of Zoe on Easy or Normal.
Complete End of Zoe on Joe Must Die.
Complete End of Zoe on Normal or Joe Must Die using no weapons.
Complete an Extreme Challenge in End of Zoe.
Perform a 4-hit combo with your bare fists in End of Zoe.
Stealth kill 5 enemies in End of Zoe.
Complete Not a Hero on Easy or Normal difficulty.
Complete Not a Hero on Professional difficulty.
