Complete all game's Trophies.
Complete all chapters on Hard difficulty setting
Complete all chapters on Medium difficulty setting
Recover all available Red Gems in the game.
Complete all chapters on Easy difficulty setting
Story Progression in Act 5 - Chapter 5 (any difficulty setting)
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Story Progression in Act 5 - Chapter 4 (any difficulty setting)
Defeat Fleming Boss
Story Progression in Act 5 - Chapter 3 (any difficulty setting)
Story Progression in Act 5 - Chapter 2 (any difficulty setting)
Defeat 50 enemies with the SKULLBLASTER
Story Progression in Act 5 - Chapter 1 (any difficulty setting)
Story Progression in Act 4 - Chapter 6 (any difficulty setting)
Defeat Justine Boss
Story Progression in Act 4 - Chapter 5 (any difficulty setting)
Defeat 50 enemies with THE DENTIST
Story Progression in Act 4 - Chapter 4 (any difficulty setting)
Story Progression in Act 4 - Chapter 3 (any difficulty setting)
Defeat 40 enemies with the SKULLFEST 9000
Defeat Giltine Grim (Sister Grim) Boss
Story Progression in Act 4 - Chapter 2 (any difficulty setting)
Story Progression in Act 4 - Chapter 1 (any difficulty setting)
Perform 5 headshots in a row with the BIG BONER
Story Progression in Act 3 - Chapter 4 (any difficulty setting)
Defeat Elliot Beast Boss
Story Progression in Act 3 - Chapter 3 (any difficulty setting)
Defeat 30 enemies with the TEETHGRINDER
Defeat 5 enemies at once using the Hot Boner
Perform a Head Shot right after a Leg Mutilation when the enemy is flying back in the air
Defeat Kauline Grim (Sister Grim) Boss
Story Progression in Act 3 - Chapter 2 (any difficulty setting)
Defeat 20 enemies with the HOTBONER
Perform 5 Head Shots in a row with any weapon except Big Boner
Story Progression in Act 3 - Chapter 1 (any difficulty setting)
Defeat Maras Grim (Sister Grim) Boss
Defeat 30 enemies with the SKULLCUSSIONER
Story Progression in Act 2 - Chapter 4 (any difficulty setting)
Defeat George Beast Boss
Story Progression in Act 2 - Chapter 3 (any difficulty setting)
Save more than 300 White Gems in your inventory
Defeat 20 enemies with the TEETHER
Story Progression in Act 2 - Chapter 2 (any difficulty setting)
Defeat George Human Boss
Story Progression in Act 2 - Chapter 1 (any difficulty setting)
Perform all 5 brutal kills on Normal Demons frozen by the Light Shot
Defeat 3 enemies at once using the Barrels of Light
Defeat 10 enemies with the Stomp Attack
Knock back 3 drinks in a row
Story Progression in Act 1 - Chapter 1 (any difficulty setting)
Start a new game for the first time. (any difficulty setting)