Win every trophy.
Remove All Borgia Flags in Rome.
Kill a guard with a broom.
Receive 100% synch in ACB and full synch in all missions of the Da Vinci Disappearance.
Complete the Da Vinci Disappearance.
Steal 5 horses from their riders, while remaining on horseback.
Beat up the 5 thirsty harlequins.
Kill a guard with the bag that drops from a lift.
Pay 500 florins to an orator, then pickpocket him afterward.
Double Assassinate from a parachute.
Win 10000 florins playing Hazard.
Kill 10 guards with a single arrow storm.
Throw a Long Weapon, Heavy Weapon, and Smoke bomb more than 10 m at a guard.
Solve all of Subject 16’s puzzles.
Discover the Shrine in the Basilica di San Pietro.
Discover the Shrine in the Catacombe di Roma.
Collect All Feathers.
Discover the Shrine in Il Colosseo.
Discover the Shrine in Palazzo Laterano.
Discover the Shrine in the Cloaca Maxima.
Jump with the parachute off the top of Castel Sant'Angelo.
Earn 3 gold medals in the Animus Virtual Training Program.
Perform an Execution Streak of 10 kills.
Complete 10 Guild Challenges.
Secure the Apple of Eden.
Complete DNA Sequence 9.
Complete DNA Sequence 8.
Complete DNA Sequence 7.
Win the highest bet at the Fights.
Burn All Borgia Towers.
Complete DNA Sequence 6.
Destroy the Bomber.
Destroy the Tank.
Destroy the Naval Cannon.
Train a recruit up to the Rank of Assassin.
Complete DNA Sequence 5.
Complete DNA Sequence 4.
Destroy the Machine Gun.
Renovate 5 buildings in the Antico district.
Recruit 3 Assassins.
Complete DNA Sequence 3.
Complete DNA Sequence 2.
Achieve 100% Synchronization in any Sequence other than Sequence 1.
Discover the Shrine in the Terme di Traiano.
Replay a Memory.
Find 1 Artifact in 2012.
Access your email in 2012.
Throw money in a well.
Find a secure place to hide and re-enter the Animus.
Complete DNA Sequence 1.
Attempt to access DNA Sequence 9 for the first time.
Reach Level 50 (Multiplayer Only).
Get every single bonus at least once (Multiplayer Only).
Get all the Co-op bonuses in 1 session (Multiplayer Only).
Kill your target and escape your pursuer in less than 10 seconds (Multiplayer Only).
During Open Conflict, kill your target and escape (Multiplayer Only).
Take the lead 10 seconds before the end of a session and go on to win (Multiplayer Only).
Kill your target while hidden in a hay bale (Multiplayer Only).
Score 750 points or more on a single kill (Multiplayer Only).
Perform a double or triple escape (Multiplayer Only).
Complete an entire Session with at least one kill (Multiplayer Only).