Beat 2 levels in a row without picking up any hearts
Kill all 7 sins
Kill Mom
Have 7 or more max red hearts at one time
Have 4 or more soul hearts at one time
Make 3 deals with the devil in one run
Obtain all trophies
Beat 2 levels in a row without taking damage
Beat the Womb for the first time
Beat the Basement 40 times
Beat the Caves 30 times
Beat the Depths 20 times
Beat the Basement/Cellar without taking damage
Beat the Caves/Catacombs without taking damage
Beat the Depths/Necropolis without taking damage
Beat the Womb/Utero without taking damage
Beat all 20 Challenges
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball
Kill Mom using the Bible
Kill Mom's Heart 3 times
Kill Mom's Heart 5 times
Kill Mom's Heart 8 times
Kill Mom's Heart 9 times
Kill Mom's Heart 10 times
Kill Mom's Heart 11 times
You are the best!
Collect all items and unlock all secrets and endings
Beat Greed Mode with Azazel
Hold 55 or more pennies at one time
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